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. 2021 Apr 28;9(5):484. doi: 10.3390/biomedicines9050484

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Concentration-response curve of WIN55,212-2 for CB-GIRK1/2-RGS4 coupling and GIRK1/2. Oocytes were co-injected with CB, GIRK1/2, and RGS4, or GIRK1/2 cRNAs. Inward K⁺ current enhancement and reduction were produced on the application of a range of different concentrations of WIN55,212-2 in the presence of HK. The positive percentage represents enhancement and the negative percentage represents reduction. Each data point is the mean ± standard deviation (SD) of three determinations from two or three batches of oocytes.