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. 2021 Apr 28;9(5):484. doi: 10.3390/biomedicines9050484

Figure 4.

Figure 4

Reduction of inward K+ currents in the CB-GIRK1/2-RGS4 coupling and GIRK1/2 in Xenopus oocytes. (A) Oocytes co-injected with CB1, GIRK1/2, and RGS4 cRNAs, (B) oocytes co-injected with CB2, GIRK1/2, and RGS4 cRNAs, and (C) oocytes injected with GIRK1/2 cRNAs were subjected to a 1-s voltage ramp protocol from −150 to +60 mV from a holding potential of −20 mV. Inward IK,basal was strongly reduced by exchanging HK to HK plus ≈ 100 μM WIN55,212-2. Typical IK,basal and IK,WIN were recorded from three to six different oocytes.