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. 2021 Apr 28;9(5):484. doi: 10.3390/biomedicines9050484

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Structures of WIN55,212-2, ∆9-THC, CBD, CP55,940, and rimonabant, and changes of inward K⁺ currents through GIRK1/2 and IRK1 produced by these cannabinoids. Structures of WIN55,212-2, ∆9-THC, CBD, CP55,940, and rimonabant are shown in (a) column. (b) Oocytes injected with GIRK1/2 and (c) oocytes injected with IRK1 were subjected to a 1-s voltage ramp protocol from −150 to +60 mV from a holding potential of −20 mV. Current enhancement or reduction was produced on the application of ≈100 μM of (A) WIN55,212-2, or 100 μM of (B) ∆9-THC, (C) CBD, (D) CP55,940, and (E) rimonabant. Typical I_K,basal and I_K,compound were recorded from three to five different oocytes.