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. 2021 Apr 28;9(5):484. doi: 10.3390/biomedicines9050484

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of effects of WIN55,212-2, ∆9-THC, CBD, CP55,940, and rimonabant on GIRK1/2. ≈100 μM of WIN55,212-2 and 100 μM of CBD, CP55,940, and rimonabant reduced inward K⁺ currents, while 100 μM ∆9-THC slightly enhanced inward K⁺ currents. The positive percentage represents enhancement and the negative percentage represents reduction. Statistical comparisons between the various experimental groups were performed by Dunnett’s multiple comparisons test of one-way ANOVA where p < 0.05 was considered significant. ****, p < 0.0001 vs. percentage for WIN55,212-2. Each data point is the mean ± SD of three determinations from two or three batches of oocytes.