Skip to main content
. 2021 Apr 25;10(5):1015. doi: 10.3390/cells10051015

Figure 2.

Figure 2

Major events in the history of PROTAC and UPS-based drug discovery and highlights of important PROTACS/E3 ubiquitin ligase-based drugs in the pipeline. (A) Timeline showing developments in the history of drug discovery in UPS with focus on PROTACs. (B) Important PROTACs/degrader drugs or inhibitors targeting E3 ligases that are currently in the clinical pipeline at the biotech startups that were founded in the second decade of E3 ubiquitin drug discovery (2011–2020). IND: investigational new drug.