Table 3.

Histological and molecular heterogeneity in PTC.

	Mutations
	EIF1AX	TP53	RAS	BRAF	TERT	RET	ALK	NOTCH1
Classical PTC	0–5%	-	H/N/KRAS 6%	55%	5–15%	5–25%	-	-
Clear cell/solid variant PTC	-	-	H/N/KRAS 30%	>55%	-	-	5%	-
Columnar variant PTC	-	-	-	33%	-	-	-	-
Tall cell variant PTC	-	-	-	80–100%	-	-	-	-
Hobnail variant PTC	-	55%	-	25%	-	-	-	5%