Fig. 3.

Efficacy outcomes. Investigator-assessed best response in target lesions per RECIST v1.1 in the ITT population (a) and Kaplan-Meier estimates of progression-free survival as assessed by the investigator in the overall ITT population and HRD subgroups (b). Data cutoff: February 20, 2020. The ITT population only includes patients with measurable disease at baseline and one or more postbaseline tumor assessment (n = 69); each bar represents data from a single patient with 0% change from baseline shown as 0.5% for visual clarity; patients with a deleterious mutation in DDR pathway genes CHEK2, ATM, RAD51C, PALB2, and BRCA1 are indicated. HRD homologous recombination deficiency; ITT intent-to-treat; PFS progression-free survival; RECIST v1.1 Response Evaluation Criteria in Solid Tumors version 1.1