Supplementary Table 1. Univariable and multivariable linear regression analyses for correlates of serum PCSK9 level without lipid-lowering medication subjects (n = 422).
Univariate |
Adjusted for age and sex |
|||||
---|---|---|---|---|---|---|
β | SE | p-value | β | SE | p-value | |
Age | −0.006 | 0.002 | < 0.001 | |||
Sex (Male = 0, Female = 1) | −0.051 | 0.027 | 0.065 | |||
Body mass index | 0.004 | 0.004 | 0.283 | |||
Waist circumference | 0.002 | 0.001 | 0.321 | |||
Systolic blood pressure | 0.002 | 0.001 | 0.040 | 0.002 | 0.001 | 0.006 |
Diastolic blood pressure | 0.002 | 0.001 | 0.047 | 0.001 | 0.001 | 0.357 |
Aspartate transaminase | 0.004 | 0.001 | < 0.001 | 0.004 | 0.001 | < 0.001 |
Alanine transaminase | 0.005 | 0.001 | < 0.001 | 0.004 | 0.001 | < 0.001 |
γ-glutamyl transferase | 0.001 | 0.0002 | < 0.001 | 0.001 | 0.0002 | < 0.001 |
Estimated GFR | 0.002 | 0.011 | 0.005 | 0.001 | 0.001 | 0.190 |
Triglycerides† | 0.150 | 0.027 | < 0.001 | 0.143 | 0.027 | < 0.001 |
Total cholesterol | 0.001 | 0.0004 | 0.014 | 0.001 | 0.0004 | 0.003 |
HDL-cholesterol | 0.0002 | 0.001 | 0.807 | |||
LDL-cholesterol | 0.001 | 0.0004 | 0.117 | |||
Lipoprotein(a)† | 0.002 | 0.014 | 0.908 | |||
HOMA-IR† | 0.060 | 0.020 | 0.003 | 0.054 | 0.020 | 0.007 |
Hs-CRP† | 0.017 | 0.010 | 0.094 | |||
Hemoglobin A1c (NGSP) | 0.071 | 0.031 | 0.021 | 0.076 | 0.030 | 0.011 |
Alcohol intake | 0.055 | 0.027 | 0.043 | 0.022 | 0.031 | 0.475 |
Current smoking | 0.052 | 0.044 | 0.234 |
The variable was represented in the original scale after analysis using log (natural) transformed values