Table 3. Stratified analyses of ischemic stroke and plasma TMAO concentrations by age, sex, BMI, smoking status, alcohol habit, history of diabetes, and history of hypertension.
| Groups | Quartile of plasma TMAO concentrations, µmol/L |
P for interaction | |||
|---|---|---|---|---|---|
| Q1 (referent): ≤ 1.53 | Q2: > 1.53–2.33 | Q3: > 2.33–3.83 | Q4: > 3.83 | ||
| Sex | 0.501 | ||||
| Male (n = 1,088) | 1 | 1.06 (0.72, 1.56) | 1.74 (1.20, 2.54) | 1.55 (1.08, 2.24) | |
| Female (n = 818) | 1 | 1.23 (0.79, 1.91) | 1.37 (0.90, 2.10) | 1.73 (1.14, 2.65) | |
| Age | 0.399 | ||||
| < 65 y (n = 1,047) | 1 | 1.21 (0.82, 1.78) | 1.43 (0.98, 2.09) | 1.44 (0.99, 2.09) | |
| ≥ 65 y (n = 859) | 1 | 1.05 (0.67, 1.65) | 1.77 (1.15, 2.72) | 1.86 (1.23, 2.83) | |
| BMI | 0.715 | ||||
| < 24 (n = 1,039) | 1 | 1.32 (0.90, 1.94) | 1.64 (1.12, 2.40) | 1.76 (1.22, 2.55) | |
| ≥ 24 (n = 867) | 1 | 0.92 (0.58, 1.44) | 1.44 (0.94, 2.20) | 1.46 (0.96, 2.23) | |
| Current smoking | 0.159 | ||||
| Yes (n = 280) | 1 | 0.56 (0.25, 1.26) | 1.50 (0.71, 3.16) | 1.28 (0.64, 2.56) | |
| No (n = 1,626) | 1 | 1.27 (0.92, 1.74) | 1.61 (1.18, 2.19) | 1.73 (1.28, 2.35) | |
| Current drinking | 0.545 | ||||
| Yes (n = 176) | 1 | 0.69 (0.21, 2.28) | 1.80 (0.69, 4.73) | 1.49 (0.56, 3.99) | |
| No (n = 1,730) | 1 | 1.19 (0.88, 1.61) | 1.58 (1.17, 2.12) | 1.68 (1.26, 2.24) | |
| History of diabetes | 0.794 | ||||
| Yes (n = 404) | 1 | 1.50 (0.74, 3.04) | 2.15 (1.06, 4.37) | 1.98 (1.03, 3.83) | |
| No (n = 1,502) | 1 | 1.07 (0.78, 1.47) | 1.48 (1.09, 2.01) | 1.54 (1.13, 2.08) | |
| History of hypertension | 0.607 | ||||
| Yes (n = 1,026) | 1 | 1.29 (0.86, 1.93) | 1.73 (1.17, 2.56) | 1.95 (1.34, 2.84) | |
| No (n = 880) | 1 | 0.98 (0.64, 1.49) | 1.41 (0.95, 2.11) | 1.34 (0.89, 2.01) | |
Data are presented as OR (95% CIs). The multivariate model was adjusted for age, sex, BMI, smoking status, alcohol habit, history of hypertension, and history of diabetes. Q, quartile; TMAO, trimethylamine N-oxide.