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. 2021 Apr 28;11(5):650. doi: 10.3390/biom11050650

Figure 5.

Figure 5

The influence of rapamycin pre-treatment (3 mg/kg, i.p.) during neonatal period before every ethanol administration on the development of CPP induced by ethanol (1.0 g/kg; 1.5 g/kg) in adult male rats (PND60–70). Data are shown as post-conditioning minus pre-conditioning time (sec) spent in the drug-associated compartment. Results are expressed as mean ± SEM of 8 subjects per group (GraphPad version 8.0 for Windows). * p < 0.05 ** p < 0.01; *** p < 0.001. R3–rapamycin 3 mg/kg; SI–shame intubation (i.g.); EtOH–ethanol intubation (i.g.).