Table 7.
Remaining vitamin D3 with respect to initial content in the tested liquid commercial products after 6 months of storage at 4, 25, and 40 °C (average ± relative standard error, n = 3).
| Vitamin D3 Content (%) after 6 Months in Oil-Based Formulations |
Vitamin D3 Content (%) after 6 months in Water-Based Formulations |
||||||
|---|---|---|---|---|---|---|---|
| 4 °C | 25 °C | 40 °C | 4 °C | 25 °C | 40 °C | ||
| M (1) | 102.0 ± 0.2 | 101.0 ± 0.1 | 98.3 ± 0.3 | M (2) | 101.5 ± 0.0 | 101.9 ± 0.9 | 102.3 ± 0.0 |
| FS (4) | 101.2 ± 0.2 | 99.7 ± 0.2 | 97.5 ± 0.2 | M (3) | 96.7 ± 0.0 | 96.0 ± 1.0 | 80.5 ± 2.0 |
| FS (6) | 91.2 ± 2.4 | 89.1 ± 0.1 | 46.8 ± 0.4 | FS (5) | 66.2 ± 2.8 | 1.5 ± 0.9 | 0.0 ± 0.0 |
| FS (8) | 102.9 ± 1.0 | 102.2 ± 0.6 | 100.2 ± 0.5 | FS (7) | 93.1 ± 0.5 | 79.4 ± 1.0 | 40.6 ± 1.2 |
| FS (9) | 76.6 ± 3.5 | 39.8 ± 2.6 | 2.3 ± 0.2 | ||||
|
Quantitative Evaluation of Vitamin D3 Stability in the Unstable Products
(First-Order Constants and Arrh. Data) | |||||||
|
k1 (4 °C)
(month−1) (CI) |
k1 (25 °C)
(month−1) (CI) |
k1 (40 °C)
(month−1) (CI) |
Arrh. eq. | R2 | Ea (kJ/mol) | ||
| FS (5) | 0.069 (0.057–0.081) |
0.610 (0.362–0.859) |
2.469 (2.141–2.797) |
y = −8613x + 28.42 |
1.000 | 71.6 | |
| FS (7) | 0.012 (0.010–0.013) |
0.038 (0.035.042) | 0.150 (0.142–0.159) |
y = −5987x + 17.08 |
0.971 | 49.8 | |
| FS (9) | 0.045 (0.032–0.058) |
0.154 (0.136–0.173) |
0.634 (0.605–0.662) |
y = −6240x + 19.33 |
0.972 | 51.9 | |
Arrh. eq.—Arrhenius equation; CI—95% confidence interval; Ea—activation energy; FS—food supplement; M—medicine.