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. 2021 Apr 30;10(5):1072. doi: 10.3390/cells10051072

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of EV-miRNA expression profiles between ASCs under study after OA-SF treatment. (A) Heat map of hierarchical clustering analysis of the normalized C_RT values of detected miRNAs with sample clustering tree at the top. The color scale reflects the absolute expression levels: red shades = high expression levels (low C_RT values) and blue shades = lower expression levels (high C_RT values). (B) Principal component analysis of the normalized C_RT values of detected miRNAs. X and Y axis show principal component 1 and principal component 2 that explain 59.6% and 40.4% of the total variance. (C) Correlation of miRNA expression levels (normalized C_RT) between the three ASC-EVs under study.