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. 2021 May 1;12(5):680. doi: 10.3390/genes12050680

Table 1.

Dysregulated miRNAs from the Dlk1-Dio3 locus in murine and human lupus.

miRNA ID Expression
Change
Sample Source
and Type
Method of
Detection
Reference
miR-154, miR-127, miR-379, miR-382, miR-433, miR-300, miR-376b, miR-394, miR-299, miR-495, and miR-329 Up MRL-lpr
splenocyte
Microarray [77]
miR-154, miR-127, miR-379, miR-382, miR-300, miR-433, and miR -411 Up MRL-lpr
Splenocyte
CD4+ T
CD8+ B
RT-qPCR [98]
miR-127 and miR-379 Up NZBWF1
splenocyte
RT-qPCR [77]
miR-127 and miR-379 Up C3.MRL-Faslpr/J
splenocyte
RT-qPCR [122]
miR-494 and miR-544 Up Human lupus
PBMCs
Taqman low density array [74]
miR-134, miR-382, miR-409, miR-411, miR-493, miR-494, miR-544, and miR-654 Up Human lupus
PBMCs
Small RNA-seq [76]
miR-494 Up Human lupus
Naïve B
Taqman array [129]
miR-485-5p, miR-543, miR-410-3p, and miR-369-5p Up Human lupus
Type IV nephritis
plasma
Small RNA-seq [123]
miR-654 and miR-134 Human lupus
Type IV nephritis with cellular crescent
Urinary exosome
Small RNA-seq [126]
miR-134, miR-433, and miR-494 Up Human
lupus nephritis
renal biopsy
Microarray [124]
miR-485-3p Up Human discoid
cutaneous lupus
skin biopsy
Taqman array [125]
miR-379 Down Human lupus
PBMCs
Taqman low density array [74]
miR-654 Down Human lupus
PBMCs
RT-qPCR [127]