Table 5.

Efficacy of milk OIT.

Author, Year	Type of Study	Type of Milk	Population (n)	Age (years)	Partial Tolerance	Complete Tolerance
Meglio P. et al., 2004 [117]	Open-label	Fresh CM	21	6–10	14.3% (40–80 mL of CM)	71.4% (200 mL of CM)
Narisety SD. et al., 2009 [118]	Open	Fresh CM	15	6–16		33% (16 g of CM proteins)
Goldberg M. et al., 2015 [119]	Open	Baked CM	14	6.5–12.7		21% (1.3 g of CM proteins)
Takahashi M. et al. 2016 [120]	Open	Microwave heated CM	31	5–17		45.2% (200 mL of CM)
Ebrahimi M. et al.2017 [121]	Open	Fresh CM	14	3.5–7		92.9% (200 to 250 mL of CM)
Skripak et al., 2008 [122]	Randomized, double-blind, placebo-controlled	Fresh CM	13	6–17		30.8% (500 mg of CM proteins)
Longo G. et al., 2008 [123]	Randomized open-label	Fresh CM	30	5–17	54% (5–150 mL of CM)	36% (> 150 mL of CM)
Pajno GB. et al., 2010 [124]	Randomized, placebo controlled	Fresh CM	15	4–10		67% (200 mL ofCM)
Martorell A. et al., 2011 [125]	Randomized, placebo controlled	Fresh CM	30	2–3		90% (200 mL of CM)
Amat F. et al.2017 [126]	Randomized	Baked CMFresh CM	43	3–10	26.8% (0.27–2.5 g of CM proteins)	36.6% (2.72 g of CM proteins)
Maeda M, et al., 2020 [127]	Randomized controlled	Fresh CM	28	3–12		50% (100 mL of CM)
Mota I. et al., 2018 [128]	Prospective	Fresh CM	42	2–18		92% (200 mL of CM)
Berti I. et al., 2019 [129]	Prospective	Fresh CM	73	3–11		97% (150 mL of CM)
De Schryver S. et al., 2019 [130]	Prospective, randomized-controlled	Fresh CM	41	6–18		73.2% (200 mL of CM)
Efron A. et al.,2018 [131]	Retrospective, case-control	Fresh CM	43	1–4		86% (250 mL of CM)
Kauppila T.K. et al., 2019 [132]	Retrospective	Fresh CM	296	5–17		56% (200 mL of CM)
Demir E. et al., 2020 [133]	Retrospective, cohort study	Fresh CM	47	3–13		89.3% (200 mL of CM)
Gruzelle V. et al., 2020 [134]	Retrospective	Baked CM	64	2–16		42.2% (254 mL of CM)