Table 4.
Univariate and multivariate analyses of prognostic factors for overall survival.
| Factor | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age, ≥65 y vs. <65 y | 1.09 (0.43–2.81 | 0.85 | - | - |
| Gender, male vs. female | 1.20 (0.50–2.88) | 0.67 | - | - |
| Smoking history, never vs. ever | 1.16 (0.49–2.75) | 0.74 | - | - |
| PS at diagnosis of advanced disease, 2 vs. 0–1 | 4.79 (1.44–15.82) | 0.01 | 8.64 (2.01–35.6) | 0.003 |
| Lines of treatment, ≤2 vs. >3 | 2.87 (1.01–8.14) | 0.05 | 4.05 (1.30–12.63) | 0.02 |
| ICB treatment, yes vs. no | 2.14 (0.88–5.20) | 0.08 | 2.88 (1.12–7.41) | 0.03 |
| PD-L1, ≥1% vs. <1% | 1.69 (0.66–4.32) | 0.27 | - | - |
| TP53, present vs. absent | 1.33 (0.52–3.40) | 0.55 | - | - |
ICB, immune checkpoint blockade; PD-L1, programmed death ligand-1; PS, performance status.