Table 2.

Angiocrine signals mediated by the regenerating zebrafish heart endothelial/endocardial cell populations. Clear rows indicate genes upregulated after cardiac injury, grey shaded rows indicate genes that are downregulated. CM—cardiomyocyte, EC—endothelial cell, EPDCs—Epicardial-derived cells, ECM—extracellular matrix, EndoMT—endothelial-to-mesenchymal transition, dn—dominant negative, Tg—transgenic.

Gene	Source	Role	Transgenic Phenotype If Known	Reference
nrg1	EPDCs	Coronary revascularisation, CM proliferation	Tg(cmlc2:CreER; β-act2:BSNrg1): Increased revascularisation and CM proliferation	[107]
notch	Endocardium Epicardium	CM proliferation and scar resorption via endocardial maturation	Tg(UAS:NCID; ET33-mi60a): endocardial maturation Tg(dn-MAML)EC: reduced CM proliferation and increased fibrosis	[112,113]
runx1	Endocardium Epicardium	EndoMT Fibrosis	runx1−/−: accelerated scar resorption and decreased fibrosis, increased CM proliferation	[133]
aldh1a2	Endocardium Epicardium	CM proliferation	Tg(Hsp70:dn-zrar): decreased CM proliferation	[135]