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. 2021 May 1;13(5):647. doi: 10.3390/pharmaceutics13050647

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetics and efficacy in protecting retinal ganglion cells (RGCs) in a rat model. (A) A single unilateral subconjunctival injection of SPC microcrystals (200 μg in 5 μL) was given in rats, and tissues were analyzed for combined sunitinib and N-desethyl sunitinib levels in the retina at the specified time points (n = 4–9). Units shown as ng combined drug per g of tissue (ng/g). Data shown as median ± IQR. (B) SPC microcrystals (200 μg in 5 μL) were injected unilaterally and an optic nerve crush procedure was performed 2 weeks prior to the indicated time points (n = 7–12). After 2 weeks, the percentage of surviving RGCs was calculated compared to the healthy fellow eye. Data shown as mean ± SD. * p < 0.05 compared to control crush animals at 3 and 20 weeks. Statistical analyses conducted by one-way ANOVA with multiple comparisons.