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. 2021 May 1;9(5):441. doi: 10.3390/vaccines9050441

Figure 1.

Figure 1

Schematic diagram of cancer stem cell-derived exosomes (CSCEXs) and their cargo. (a) General exosomal markers. (b) The content unique to tumor-derived exosomes [55]. (c) CSCEXs promote cancer stemness, epithelial–mesenchymal transition (EMT)/metastasis, and tumor angiogenesis, and contribute to immunosuppression in the tumor microenvironment [52]. CSCEXs mediate multiple actions through the delivery of microRNA (miR), long non-coding RNA (lncRNA), circular RNA (circRNA), proteins, cytokines, or transcription factors.