Table 3:
Exosome clinical study application on different diseases model other than brain and cancer
| No | Disease and Conditions | Interventions and Exosome source | Therapeutic used in the study | Trial Identification Number | Status & Clinical Phase |
|---|---|---|---|---|---|
| 1 | Ulcer | Plasma-derived exosomes | The objective is to evaluate the effect of autologous exosome rich plasma on cutaneous wound healing | NCT02565264 | Enrolling by invitation & Early Phase 1 |
| 2 | Myocardial infarction | Exosomes in peripheral blood of patients | Expression of miRNA with healthy volunteers, explore its relationship with the development of myocardial infarction | NCT04127591 | Not yet recruiting, & Not applicable |
| 3 | Sepsis | Drug: Antibiotics, Blood exosomes | To compare peripheral blood dendritic cell-derived exosome changes in patients with sepsis with healthy controls. | NCT02957279 | Unknown & Not applicable |
| 4 | Polycystic ovary syndrome | Ginger exosomes, Aloe exosomes placebo | Ginger or aloe plants exosomes will treat and improve the condition of polycystic ovary syndrome | NCT03493984 | Recruiting & Not applicable |
| 5 | Preeclampsia, cardiovascular disease | Exosomes from maternal blood and placental tissue in patients diagnosed with preeclampsia | The functional role of exosomal cargo in normal and pathological pregnancies and point towards novel therapeutic intervention strategies. | NCT04154332 | Not yet recruiting & Not applicable |
| 6 | Diabetes mellitus type 1 | Mesenchymal stem cells exosomes | Intravenous infusion of cell-free umbilical cord-blood derived MSC exosomes may reduce the inflammatory state and improve the β-cell mass. | NCT02138331 | Unknown & Phase 2, Phase 3 |
| 7 | Atrial fibrillation | Epicardial fat biopsy | Investigates the role of epicardial fat-derived exosomes in patients who suffer from atrial fibrillation. | NCT03478410 | Recruiting & Not applicable |
| 8 | Kidney transplantation | Urinary exosomes | Prevalence of NCC activation three months after transplantation inpatient treated by CNI. | NCT03503461 | Completed & Not applicable |
| 9 | Healthy | High salt diet followed by a low salt diet and vice versa | Changes in the epithelial sodium channel (ENaC) of the kidney are reflected in the urinary exosomes, | NCT02823613 | Active, not recruiting & Not applicable |
| 10 | Hemodynamic instability autophagy | Blood and urine specimens | Exosomes purified in blood and urine and proteomics studies to analyze autophagy and apoptosis-related biomarkers of exosomes by bioinformatics. | NCT03267160 | Active, not recruiting & Not applicable |
| 11 | Macular holes | Exosomes derived from mesenchymal stem cells from the human umbilical cord | Exosome isolation sequential ultracentrifugation confirmed via spectral-domain optical coherence tomography (OCT) and the minimum linear diameter (MLD). | NCT03437759 | Recruiting & Early Phase 1 |
| 12 | Blood coagulation, platelet function | Exosomes from red blood cells | Analyze the effect red blood cell exosomes units have on blood coagulation and platelet function. | NCT02594345 | Completed & Not applicable |
| 13 | Healthy | Erythropoietin, placebo | The diagnostic value of differentially regulated exosome proteins could be further validated against the existing IEF EPO WADA accredited tests. | NCT03700515 | Recruiting & Not applicable |
| 14 | Preeclampsia | Umbilical cord mesenchymal stem cell exosomes | To identify miRNAs 136, 494, and 495 genes expression in the exosomes between peripheral blood, andumbilical cord mesenchymal stem cells. | NCT03562715 | Completed & Not applicable |
| 15 | Sepsis with multiple organ dysfunction (MOD) | Exosomes from macrophage co-culture with human cells, blood, and urine. | Proteomics studies in exosomes from cell culture and clinical specimens. analyze ubiquitination, autophagic, and apoptosis-related biomarkers of exosomes by bioinformatics. | NCT03222986 | Recruiting & Not applicable |
| 16 | Prehypertension | Urine exosomes | To characterize changes in urine electrolytes and exosome protein. | NCT04142138 | Not recruiting yet & Not applicable |
| 17 | Exercise physiology | Age, Genes, Training, Tickborne Disease, and Endurance | Investigate potential relationships between age, training intensity, training volume, genes, exosomes, and history of tick-borne disease and physiological variables and endurance performance. | NCT03569566 | Enrolling by invitation & Not applicable |
| 18 | Overweight children with type 2 diabetes risk | Exosomes from blood samples. | microRNA profiling in circulating exosomes and in blood peripheral mononuclear cells in pre-adolescents with high risk to develop T2D. | NCT03027726 | Completed & Not applicable |
| 19 | Diabetic retinopathy (DR) | Hematological examination, ophthalmic examination. Serum exosomes | Significant associations between DR progression and different exosomal miRNA using various statistical methods. | NCT03264976 | Not recruiting yet & Not applicable |
| 20 | Spinal disease | Urine & blood exosomes | Exosomes have the potential of being simple biomarkers that can diagnose postoperative delirium and predict cognitive decline. | NCT04120272 | Not yet recruiting & Not applicable |
| 21 | CKDu, arterial stiffness | Arterial stiffness assessment, serum, and urine biomarker | To characterize their disease profile using analysis serum and renal urine biomarkers, exosomes, proteomics, and DNA adducts. | NCT02226055 | Completed & Not applicable |
| 22 | Normal cellular metabolism | Somatostatin glucagon, exosome derived from the arterial-venous supply of tissues. | Study the exosomes derived from the arterial-venous supply of tissues related to the TCA cycle activity. | NCT02748369 | Active, not recruiting & Phase 1 |
| 23 | Hypertension | Urine samples | The study is to determine the concentrations and variabilities of urinary exosomal sodium channels and plasma angiotensins. | NCT03034265 | Completed & Not applicable |
| 24 | Chronic kidney failure, dialysis related complication | Mixed online hemodiafiltration, High flux bicarbonate dialysis, plasma exosomes | Quantitative micro-RNA changes in plasmatic exosome/microvesicles assessed by quantitative real-time PCR, Quantitative changes in C-Reactive Protein, Neutrophil Gelatinase associated Lipocalin, Interleukin-6, Ferritin. | NCT03202212 | Completed & Phase 1, Phase 2 |
| 25 | Uveitis, vasculitis, ocular inflammatory disease | Optic fluid, exosomes present in vitreous and AC fluid in the eye | Kinds of cytokines, lymphokines, biomarkers, proteome, and exosomes present in vitreous and AC fluid in the eye with uveitis or other retinal diseases. | NCT00331331 | Completed & Not applicable |
| 26 | Port-wine stain | Biopsy sample from Port Wine Stain Birthmark, Blood exosomes | Blood samples to characterize exosomes and metabolites from Port Wine Stain. | NCT02051101 | Active, Not recruiting & Not applicable |
| 27 | Diabetes mellitus, type 1 diabetes diabetes. | Insulin deprivation in type 1 diabetic patients, exosomes blood | Transient insulin deprivation in adolescents and T1DM adults alter the circulating blood and metabolome exosome contents | NCT03392441 | Active, not recruiting & Not applicable |
| 28 | Type1 diabetes mellitus, type2 diabetes, | Human blood samples, beta-cell exosomes | In this study, beta-cell derived exosomes will be detected and characterized in human blood samples. | NCT03106246 | Unknown |
| 29 | Sepsis | Blood & serum exosome | miRNA expression levels in exosomes, serum, and blood cells. | NCT03280576 | Complete & Not applicable |
| 30 | Obesity | Early time-restricted feeding, structured weight loss program, urine exosome | Urine exosomes will be analyzed in 12-hour bins to determine how meal timing affects these endpoints differentially during the daytime and nighttime. | NCT03459703 | Recruiting & Not applicable |
| 31 | Barretťs esophagus, gastroesophageal reflux, esophageal adenocarcinoma | Blood exosomes | Measure for a biomarker called microRNA (miRNA) using exosomes. | NCT02464930 | Unknown & Not applicable |
| 32 | Childhood chronic kidney disease | Urine exosomes | Molecular value (ADMA & urine exosome miRNA), | NCT03227055 | Recruiting & Not applicable |
| 33 | Chronic Ulcer | Conditioned media, opical Antibiotic Combinations, Exosome from cell medium | Study to see the therapeutic potentials of Conditioned Medium Stem Cell as an additional growth factor in chronic skin ulcer healing and to compare the success of chronic ulcer healing | NCT04134676 | Not yet recruiting & Phase 1 |
| 34 | COPD, emphysema chronic bronchitis airway obstruction smoking, tobacco, gender | Exosomes from lung cells. | Alterations at the epigenetic, mRNA, microRNA, proteome, metabolome, and microbiome level will perform from multiple lung compartments | NCT03049202 | Recruiting & Not applicable |
| 35 | Hypertension | sodium phosphate sevelamer, sodium bicarbonate, sodium chloride Plasma and urine sample | Changes in NaPi-IIa assessed from urinary exosomes. | NCT02822131 | Completed & Not applicable |
| 36 | Thyroid disease, heart failure | Urine sample | Investigators will enroll clinical and subclinical thyroid disease with quarterly follow-up then detect urine exosomal proteins NT-proBNP. | NCT03984006 | Recruiting & Not applicable |
| 37 | Drug-resistant epilepsy | Blood sample | Expression profile of miRNAs in the plasma as well as in the exosomes. | NCT03419000 | Recruiting & Not applicable |
| 38 | Panic disorder | Serum sample | Changes in exosomal microRNAs (miRNAs) from serum samples taken before an Disorder d after CBT (PD) patients from Panic | NCT04029740 | Recruiting & Not applicable |
| 39 | Diabetes | Dual energy X-ray, adipose tissue biopsy, blood sample | New biomarkers of adult-onset autoimmune diabetes. | NCT03971955 | Recruiting & Not applicable |
| 40 | Aging, cognitive, ketones, blood sugar | Jardiance 25 mg, Plasma exosomes | The study is an increased expression of receptors and mediators of ketone metabolism in plasma exosomes. | NCT03852901 | Recruiting & Phase 1 |
| 41 | Diabetes mellitus, type 2 diabetes, cardiovascular diseases | Dapagliflozin 10 mg, Saxagliptin 5 mg, Urine exosomes | In addition to Dapagliflozin (additive effect), Saxagliptin may improve EPC number and function even more than Dapa alone, compared to placebo. | NCT03660683 | Recruiting & Phase 4 |
| 42 | Insulin resistance | Rosiglitazone versus placebo, response to amiloride infusion & furosemide infusion, Urine exosomes | The difference in the ENac abundance in exosomes in the urine measured after eight weeks of treatment with either rosiglitazone or placebo. | NCT00285805 | Completed & Not applicable |
| 43 | Childhood obesity, adolescent obesity | Behavioral: Exercise, Serum exosomes | Looking for circulating exosome-derived miRNA in plasma. | NCT03762629 | Recruiting & Not applicable |
| 44 | Fibrosis, kidney transplant failure, kidney allograft, and rejection | Observational (a urinary biomarker for kidney allograft fibrosis), urine exosomes | Urinary exosomes are isolated and analyzed transglutaminase type 2 | NCT03487861 | Recruiting & Not applicable |
| 45 | Obstructive sleep apnea, morbid obesity, epigenetic disorder | CPAP, bariatric surgery, blood sample, exosome mRNA | Differences in miRNA profile among patients with morbid obesity with or without OSA. | NCT03995836 | Completed & Not applicable |
| 46 | HIV infection, tuberculosis Infection | Detection of molecular biomarkers, plasma exosomes | Description of miRNA expression profile in a cohort of patients with an HIV infection and Tuberculosis and correlate it with their clinical evolution. | NCT03941210 | Recruiting & Not applicable |
| 47 | Obstructive sleep apnea of adult, hypoxia, sleep disorder, stroke, endothelial dysfunction, oxidative stress | Drug lowering cerebral blood flow (CBF) and normoxia sleep, urine exosomes, placebo, and intermittent hypoxia sleep. blood sample, | Vascular biomarkers exosome analysis or urinary prostaglandins before and after sleep under normoxia and intermittent hypoxia exposure with cerebral blood flow changes. | NCT03255408 | Not yet recruiting & Phase 1 & 2 |
| 48 | Muscular dystrophy, neuromuscular diseases, X-Linked genetic diseases, inborn | Cardiosphere-derived cell exosomes. | Evaluating the safety and efficacy of a cell therapy called CAP-1002. | NCT03406780 | Active not recruiting & Phase 2 |
| 49 | Heart Failure with Preserved Ejection Fraction | Drug: 0.9% Sodium Chloride, Furosemide 40 mg | Sodium transporters in Urinary exosomes will be characterized and compared between HFpEF patients and controls. | NCT03837470 | Recruiting & Early Phase 1 |
| 50 | Obesity, insulin resistance | Mediterranean diet, ketogenic diet, Blood and Adipose tissue exosomes | Signaling between organs and cells will be examined by isolating exosomes from blood and adipose tissue | NCT04131166 | Recruiting & Not applicable |
| 51 | Thoracic surgery, video-assisted | two-lumen catheter, chest tube, plasma sample exosomes | Diagnostic value and molecular characteristics of plasma exosome-derived miRNAs for these patients. | NCT03230019 | Recruiting & Not applicable |
| 52 | Healthy older adults ages 65–89 | Blood, CSF, and serum exosomes | Different biomarkers may relate to immune health and the aging process, the risk for cognitive decline, and Alzheimer’s disease. | NCT03944603 | Recruiting & Not applicable |
| 53 | Obesity, insulin resistance | Blood and adipose tissue exosomes | Signaling between organs and cells will be examined by isolating exosomes from blood and adipose tissue. | NCT02706262 | Recruiting & Not applicable |
| 54 | Body weight changes | Moderately high protein diet, low-fat diet, serum exosome mRNA | MicroRNAs levels in exosomes will be measured by NGS Illumina Myseq at baseline and the end of the bodyweight-loss period | NCT02737267 | Unknown & Not applicable |
| 55 | Rhinitis, allergic, perennial | Exosomes from blood, saliva, serum, and plasma | Exosome Isolation Reagent (for plasma or serum) will compare the change in exosomes before and after treatment. | NCT02653339 | Unknown & Not applicable |
| 56 | Exosome | Endometrial fluid collection, serum, blood exosomes | To describe the morphology, size distributions, and specific markers of the different vesicle’s populations present endometrial fluid (i.e., DNA, RNA, proteins, lipids) | NCT02797834 | Unknown & Not applicable |
| 57 | Non-alcoholic fatty liver disease | Tofogliflozin, glimepiride | Changes from baseline in microRNAs and exosome contents. | NCT02649465 | Recruiting & Phase 4 |
| 58 | Chordoma | Drug: Afatinib Blood samples | Pharmacokinetic study and translational studies on EGFR pathway activation and signaling on blood and tumor samples. | NCT03083678 | Recruiting & Phase 2 |
| 59 | Minimal Residual disease, recurrent acute&myelodysplasia recurrent childhood acute myeloid leukemia | Daratumumab, Donor Lymphocyte Infusion, Laboratory Biomarker Analysis | The donor lymphocytes and monoclonal antibodies, such as daratumumab, may kill the remaining cancer cells. | NCT03537599 | Recruiting & Phase 1&2 |
| 60 | Dystrophic epidermolysis bullosa | AGLE-103 is an allogeneic derived exosomes product derived from healthy donor mesenchymal stem cells (MSCs), placebo | To assess the safety and effectiveness of AGLE-103 vs. placebo on lesions in subjects with EB. | NCT04173650 | Not yet recruiting & Phase 1, Phase 2 |
| 61 | Type-1 diabetes | Circulating β-cell exosomes | To diagnose the disease and its progression in type 1 diabetes. | NCT04164966 | Not yet recruiting & Not applicable |
| 62 | Fasting | Time-restricted feeding (TRF) with dietary counseling, blood exosomes | Safety and compliance, as well as the efficacy of one specific IF intervention called time-restricted feeding. | NCT04184076 | Not yet recruiting & Phase 2 |
| 63 | COPD | Blood, stool, urine, saliva, serum exosomes | Exosome characterization of COPD patients and healthy controls. | NCT04183530 | Recruiting & Not applicable |
| 64 | Dry eye | Mesenchymal stem cells derived | Umbilical Mesenchymal Stem Cells (UMSC) derived exosomes for chronic Graft Versus Host Diseases (cGVHD) treatment | NCT04213248 | Not yet recruiting & Phase 1, Phase 2 |
| 65 | Sleep apnea, inflammation, atherosclerosis | Myeloid PTP1B expression analysis, blood exosomes | To investigate myeloid PTP1B involvement in the vascular pro-inflammatory process described in OSA. | NCT04235023 | Not yet recruiting, not applicable |
| 66 | Coronavirus | MSCs-derived exosomes | Efficacy and safety of aerosol inhalation of the exosomes derived from allogeneic adipose mesenchymal stem cells (MSCs-Exo) | NCT04276987 | Not yet recruited & Phase 1 |
| 67 | Corona infection, virus pneumonia | T-cell-derived exosomes | Safety and efficacy of this new targeted delivery by metered-dose inhaler | NCT04389385 | Active but not recruiting & Phase 1 |
| 68 | Pulmonary Nodule | Blood and alveolar lavage of lung nodules patients | Study the sensitivity, specificity, and diagnostic accuracy of ctDNA and exosome combined detection in the identification of benign and malignant pulmonary nodules | NCT04182893 | Recruiting & Not applicable |
| 69 | Periodontitis | Adipose-derived stem cells exosomes | The adipose stem cell exosomes are isolated autogenously from the patient to be injected locally into the periodontal pockets to evaluate their regenerative effect. | NCT04270006 | Recruiting & Early Phase 1 |
| 70 | Healthy control | Low level of MSCs-Exo, High level of MSCs-Exo | Safety and tolerance of aerosol inhalation of the exosomes derived from allogeneic adipose mesenchymal stem cells (MSCs-Exo) | NCT04313647 | Recruiting & Phase 1 |
| 71 | Healthy elderly | IkT-148009 & placebo, CNS-deriver exosomes | Investigates the safety tolerability movement of drug IkT-148009 in healthy elderly volunteers. | NCT04350177 | Not yet recruiting & Phase 1 |
| 72 | Heart failure | Exercise training, plasma exosome | Plasma exosomes will be isolated using microbead-based sorting techniques and characterized | NCT04334603 | Recruiting & Not applicable |
| 73 | Empagliflozin, hypoglycemic agents, sodium-glucose transporter 2 Inhibitors | Jardiance 25 mg, plasma exosomes | Determine expression of receptor and mediators of ketone metabolism in plasma exosomes. | NCT03852901 | Recruiting & Phase 1 |
| 74 | Multiple system atrophy | Blood, and plasma exosomes. | The study is to complete the target validation of insulin resistance for future treatment trials. | NCT04250493 | Not yet recruiting & Not applicable |
| 75 | Multiple organ failure | MSC exosomes | To evaluate the safety and efficacy of exosomes from MSCs to determine clinical dosage for patients with severe MODS | NCT04356300 | Not yet recruiting & Not applicable |
| 76 | Oocyte maturation | Follicular fluid exosomes | Investigate the miRNA in (follicular fluid) FF exosomes in young and aged women and their relationship to egg maturation | NCT04382872 | Not yet recruiting & Not applicable |
| 77 | Corona virus Infection, COVID-19, SARS | Organicell Flow, placebo | Safety and efficacy of intravenous infusion of Organicell Flow | NCT04384445 | Not yet recruited & Phase 1, 2 |
| 78 | Coronavirus | MSCs-derived exosomes | The efficiency of aerosol inhalation of the exosomes derived from allogeneic adipose mesenchymal stem cells (MSCs-Exo) | NCT04276987 | Complete, Phase 1 |
| 79 | Drug resistance exosomes | MPCs-derived | Evaluate the efficacy and safety of haMPC-exosome treatment with pulmonary infection caused by gram-negative bacilli resistant to carbapenems. | NCT04544215 | Recruiting, Phase 1 & 2 |
| 80 | Endothelial dysfunction, obese, OSA patients | Circulating exosome, mRNA analysis. | Evaluation of miRNA contained in exosomes | NCT04459182 | Not yet recruiting, not applicable |
| 81 | Kidney transplantation | Urine exosome analysis | Urine exosome analysis after kidney transplantation | NCT03503461 | Complete, not applicable |
| 82 | Covid19, SARS-CoV-2 pneumonia, COVID-19 | Mesenchymal stem cells exosomes | Inhalation of exosomes may reduce inflammation and damage to the lung tissue and stimulate the regenerative processes. | NCT04602442 | Enrolled by invitation, Phase 2 |
| 83 | Covid19, SARS-CoV-2 Pneumonia, COVID-19 | Mesenchymal stem cells exosomes | Inhalation of exosomes may reduce inflammation and damage to the lung tissue and stimulate the regenerative processes. | NCT04491240 | Complete, Phase 1& 2 |
| 84 | Acute respiratory distress syndrome | Human mesenchymal stem cell exosome | To evaluate allogeneic human mesenchymal stem cell exosomes (hMSC-Exos) in the treatment of acute respiratory distress syndrome | NCT04602104 | Not yet recruiting, Phase 1 &2 |
| 85 | Healthy control | Mesenchymal stem cells (MSCs) exosomes | Evaluate aerosol inhalation’s safety and tolerance of the exosomes derived from allogeneic adipose mesenchymal stem cells (MSCs-Exo) in healthy volunteers. | NCT04313647 | Recruiting, Phase 1 |
| 86 | Macular holes | Mesenchymal stem cells (MSCs) exosomes | Efficacy and safety of MSC-derived exosomes (MSC-Exos) for promoting healing of large and refractory macular holes (MHs) | NCT03437759 | Recruiting, early phase 1 |
| 87 | Blood coagulation, platelet function | Red derived exosomes blood- | To analyze the effect exosomes derived from red blood, cell units have blood coagulation and platelet function. | NCT02594345 | Complete, Not applicable |
| 88 | Metabolism, acute resistance exercise | Muscle exosomes | Exercise-induced skeletal muscle exosomes promote adipocyte lipolysis | NCT04500769 | Recruiting, not applicable |
| 89 | Allergic asthma, severe eosinophilic asthma | rEOS- and iEOS-derived exosomes | Qualitative and quantitative selected ncRNA levels in lung resident EOS- and inflammatory EOS-derived exosomes | NCT04542902 | Recruiting, Not applicable |
| 90 | Jaundice, Neonatal | Breast milk exosomes. | Analysis of breast milk exosomes miRNA for hyperbilirubinemia Neonatal | NCT04527536 | Notrecruiting yet, not applicable |
| 91 | Diabetes mellitus type 2, gestational diabetes, Overweight and obese, Pregnancy in diabetic, Insulin resistance, Insulin sensitivity, Pregnancy, High Risk | Serum plasma exosomes and | The level, content, and bioactivity of exosomes in serum and plasma Versus Insulin sensitivity | NCT04617405 | Not yet recruiting, not applicable |
| 92 | Lupus nephritis | Urine and serum exosomes | Analyze urine and serum exosome biomarkers | NCT04534647 | Recruiting, Not applicable |
| 93 | Acute myeloid leukemia | Bone marrow and peripheral blood exosomes | Analysis of exosomes and microvesicles derived from PB and bone marrow samples of AML patients | NCT04460963 | Not yet recruiting, not applicable |
| 94 | Polycystic kidney disease, autosomal dominant | Urine exosomes | Changes in polycystin-1 (PC-1) and polycystin-2 (PC-2) protein levels in urinary exosomes from baseline to Day 44 | NCT04536688 | Recruiting, Phase 1 |
| 95 | COVID-19 | Cardiosphere-derived cells (CDCs) exosomes | CDC exosome ability to be immunomodulatory, anti-fibrotic, and regenerative. | NCT04623671 | Recruiting, Phase 2 |
| 96 | Covid19 ARDS pneumonia, viral | Bone marrow-derived exosomes | Safety and efficacy of intravenous administration of bone marrow-derived exosomes | NCT04493242 | Not yet recruiting, Phase 2 |
| 97 | Non-alcoholic fatty liver disease, Metabolic syndrome, metabolically abnormal & metabolically normal obesity, obesity | Liver exosomes | To determine the specific cellular and organ system, metabolic and immunologic alterations via analyzing liver exosomes. | NCT01104220 | Recruiting, not applicable |
| 98 | SARS (Severe Acute Respiratory Syndrome) | Blood exosomes | Blood filtration using Hemopurifier and blood exosome analysis. | NCT04595903 | Not yet recruiting, not applicable |
| 99 | Systemic autoimmune diseases | Plasma and urine exosomes | Exosomes for biomarker screening, gene expression analysis | NCT02890134 | Unknown, not applicable |
| 100 | Systemic autoimmune diseases | Urine and plasma exosome | Exosomes for biomarker screening, gene expression analysis | NCT02890121 | Complete, Not applicable |