Table 2.
Differential association of antibodies against VLPs and L1 from HPV16 and 18 in women with uterine cervical lesions and HPV-vaccinated.
| Anti-VLPs Seropositivity | |||||||||||
| Variable | Total | HPV16 (n = 49) | HPV18 (n = 25) | ||||||||
| n | n | (%) | OR | (CI 95%) | p | n | (%) | OR | (CI 95%) | p | |
| Population Group | |||||||||||
| Normal Adult | 68 | 5 | (7.4) | 1.00 | 0 | (−) | |||||
| CIN1-2 | 23 | 2 | (8.7) | 1.20 | (0.21–6.65) | 0.835 | 2 | (8.7) | 1.00 3 | ||
| CIN3/CC | 39 | 6 | (15.4) | 2.29 | (0.65–8.07) | 0.197 | 1 | (2.6) | 0.27 | (0.23–3.23) | 0.305 |
| Vaccinated | 36 | 36 | (100.0) | 2.11 × 108 | 0.000 | 22 | (61.1) | 16.50 | (3.33–81.53) | 0.001 | |
| No. sexual partners last year | |||||||||||
| 0–1 | 99 | 23 | (23.2) | 1.00 | 14 | (14.1) | 1.00 | ||||
| ≥2 | 67 | 26 | (38.8) | 2.09 | (1.06–4.12) | 0.032 | 11 | (16.4) | 1.19 | (0.50–2.81) | 0.688 |
| Smoking 1 | |||||||||||
| No | 112 | 28 | (25.0) | 1.00 | 14 | (12.5) | 1.00 | ||||
| Yes | 28 | 16 | (57.1) | 3.99 | (1.68–9.47) | 0.002 | 10 | (35.7) | 3.88 | (1.49–10.10) | 0.005 |
| Anti-L1 Seropositivity | |||||||||||
| Variable | Total | HPV16 (n = 40) | HPV18 (n = 32) | ||||||||
| n | n | (%) | OR | (CI 95%) | p | n | (%) | OR | (CI 95%) | p | |
| Population Group 2 | |||||||||||
| Normal Adult | 68 | 1 | (1.5) | 1.00 | 3 | (4.4) | 1.00 | ||||
| CIN1-2 | 23 | 1 | (4.4) | 3.04 | (0.18–50.75) | 0.438 | 1 | (4.4) | 0.98 | (0.97–9.96) | 0.990 |
| CIN3/CC | 39 | 6 | (15.4) | 12.18 | (1.40–105.38) | 0.023 | 3 | (7.7) | 1.80 | (0.34–9.41) | 0.483 |
| Vaccinated | 36 | 32 | (88.9) | 536.0 | (57.55–4991.7) | 0.000 | 25 | (69.4) | 49.2 | (12.67–191.3) | 0.000 |
| No. sexual partners last year | |||||||||||
| 0–1 | 99 | 18 | (18.2) | 1.00 | 16 | (16.1) | 1.00 | ||||
| ≥2 | 67 | 22 | (32.8) | 2.20 | (1.06–4.52) | 0.032 | 16 | (23.9) | 1.62 | (0.74–3.53) | 0.219 |
| Smoking 1 | |||||||||||
| No | 112 | 20 | (17.9) | 1.00 | 17 | (15.2) | 1.00 | ||||
| Yes | 28 | 15 | (53.6) | 5.30 | (2.18–12.87) | 0.000 | 13 | (46.4) | 4.84 | (1.96–11.96) | 0.001 |
1 There are 26 missing data. 2 AUC = 0.63 for the logistic regression model for anti-L1-16 antibodies of the studied population without considering the vaccinated group. 3 The CIN1-2 group was used as a reference for the regression model.