Table 4. Multivariable-Adjusted Hazard Ratios for Composite Endpoint According to the Baseline Risk Category.

	No previous vascular disease at baseline		Previous vascular disease at baseline
	< 3 risk factors (n = 2,010)	≥ 3 risk factors (n = 319)	Single-vascular disease (n = 975)	Multivascular disease (n = 200)
	Hazard Ratio (95% CI)a
Model 1	1.00 (reference)	1.22 (0.99–1.50)	1.80 (1.58–2.04)	2.24 (1.80–2.79)
Model 1 + systolic blood pressure	1.00 (reference)	1.21 (0.98–1.48)	1.78 (1.56–2.02)	2.24 (1.80–2.79)
Model 1 + RASB	1.00 (reference)	1.18 (0.95–1.45)	1.76 (1.54–2.00)	2.21 (1.77–2.75)
Model 1 + systolic blood pressure + RASB	1.00 (reference)	1.17 (0.95–1.45)	1.75 (1.53–1.99)	2.21 (1.78–2.75)

Abbreviations: CI, confidence interval; CAD, coronary artery disease; PAD, peripheral arterial disease; MACE, major adverse cardiovascular events; RASB, renin-angiotensin system blockade; VDRA, vitamin D receptor activator.

Three-point MACE was defined as a composite of cardiovascular death, nonfatal CAD, and nonfatal stroke.

The composite endpoint was defined as a composite of the three-point MACE and PAD.

Model 1 was adjusted for age, sex, dialysis duration, diabetes, hemoglobin concentration, serum albumin, Ca × iP products, intact-PTH, total cholesterol, and log-transformed C-reactive protein, Kt/V (patient clearance, dialysis time, urea space), body mass index, and use of VDRA.