Table 6. Multivariable Independent Predictors of New-onset Multivascular Disease in the Cox regression Model.
| Variable | Hazard Ratio (95% CI)a | P value |
|---|---|---|
| Multivascular disease (vs. no vascular disease) | 2.59 (1.38–4.89) | < 0.01 |
| Diabetes (vs. no) | 2.29 (1.70–3.09) | < 0.01 |
| Single-vascular disease (vs. no vascular disease) | 1.82 (1.24–2.68) | < 0.01 |
| Use of RASB (%) | 1.81 (1.36–2.41) | < 0.01 |
| Age (per 10 year increment) | 1.33 (1.17–1.52) | < 0.01 |
| Log-transformed serum C-reactive protein (per 1 log [mg/dL] increment) | 1.16 (1.06–1.27) | < 0.01 |
| Ca × iP products (per 10 increment) | 1.15 (1.03–1.30) | 0.02 |
| Systolic blood pressure (per 10 mmHg increment) | 1.13 (1.07–1.21) | < 0.01 |
Abbreviations: CI, confidence interval; CAD, coronary artery disease; RASB, renin-angiotensin system blockade; VDRA, vitamin D receptor activator.
Multivascular disease was defined as a composite of cardiovascular death, nonfatal CAD, and nonfatal stroke.
a
Adjusted for age, sex, dialysis duration, diabetes, systolic blood pressure, hemoglobin concentration, serum albumin, Ca × iP products, intact-PTH, total cholesterol, and log-transformed C-reactive protein, Kt/V (patient clearance, dialysis time, urea space), body mass index, and use of RASB and VDRA.