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The modular structure of the fibulin family. The eight members of the fibulin family have a similar arrangement and consist of three modules, grouped as domain-I, -II, and -III. Fibulin-5 is the only member of the fibulin family that displays evolutionarily conserved arginine–glycine–aspartic acid (RGD) sequence, which promotes binding to the cell surface integrin receptors. Hemicentins display a unique von Willebrand factor domain.
