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. 2021 May 2;11(5):685. doi: 10.3390/biom11050685

Figure 2.

Figure 2

Interaction of fibulin-1 and fibulin-2 proteins with a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of metalloproteases in breast cancer cells. The interaction of fibulin-1 with ADAMTS-1 promotes an anti-tumor activity by removing VEGF, a key mediator in cancer development. The interaction of fibulin-2 with ADAMTS-12 reduces the invasive and migration capacity of cancer cells, and thus promotes its anti-tumor activity. In contrast, fibulin-2 interaction with ADAMTS-4 and ADAMTS-5 promotes the tumor activity by increasing the invasive and migration capacity of cancer cells.