Table 1.

Size, chromosome location, and expression pattern of fibulins.

S.No.	Types of Fibulins	Size (kDa)	Gene Location	Location in ECM	Expression Pattern	References
1.	Fibulin-1	90-100	22q13.31	Fibril matrix	Cartilage, developing limbs, developing myotomes, perichondrial structures, neural crest cells, and endocardial cushion tissue	[7,26,45]
2.	Fibulin-2	~195	3p24-p25	Basement membrane	Developing heart, smooth muscle precursor cells, developing cartilages, neural crest cells, and endocardial cushion tissue	[40,42]
3.	Fibulin-3	~50	2p16	Basement membrane	Cartilage, developing bones, and developing cranial area	[50]
4.	Fibulin-4	~50	11q13	The interface between the fibrillin microfibrillar scaffold and the elastin core	Heart, skeletal muscle, placenta, lungs, pancreas, brain, and kidney	[2]
5.	Fibulin-5	~65	14q32.1	Basement membrane	Developing artery, neural crest cells, mesenchymal tissues, endothelial cushion tissue, heart, lungs, and uterus	[39,65,66,91]
6.	Fibulin-6	~600	1q25.3	Basement membrane	Retinal endothelial and epithelial cells, and skin fibroblasts	[3,39,86]
7.	Fibulin-7	~48	2q13	Pericellular region	Cartilage, placenta, teeth, and hair follicles	[10]
8.	Fibulin-8	~600	9q34.11	Basement membrane	Developing somites and mesenchymal cells in zebrafish	[39,90]