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. 2021 May 2;9(5):448. doi: 10.3390/vaccines9050448

Figure 2.

Figure 2

Therapeutic effects of LEAPS vaccine treatment on arthritis in GIA mice in the introductory study (study 1). LEAPS therapy was initiated in the GIA mice on days 0 and 14 after the onset of arthritis (visual arthritis score ~3 in each group, n = 8 mice per group). All treatments were administered in adjuvant. Arthritis severity was assessed by visual scoring 3 times a week for 5 weeks. The treatment groups were as follows: PBS in adjuvant (adjuvant control) represented in black; LEAPS conjugate DerG-PG70 (CEL-4000), represented in red; LEAPS conjugate DerG-PG275Cit, represented in blue; Combination of CEL-4000 and DerG-PG275Cit, represented in green. Disease severity was significantly suppressed (reduced arthritis score) in mice treated with LEAPS vaccines as compared with the adjuvant-treated control group. The 2-way repeated measures ANOVA was used for statistical analysis (see Supplemental Table S1 for p values of visual arthritis scores and other details).