Figure 4.

Therapeutic effects of LEAPS vaccine treatment on arthritis in GIA mice in the confirmatory study (study 2). LEAPS therapy was initiated in the GIA model after the onset of arthritis. The groups and treatment protocols for control (adjuvant) and LEAPS administration were the same as in Figure 2. Disease severity was significantly suppressed (as indicated by reduced arthritis score) in mice treated with LEAPS vaccines as compared with the adjuvant-treated control group (n = 8 mice per group). The 2-way repeated measures ANOVA was used for statistical analysis (see Supplemental Table S2 for p values of visual arthritis scores and other details).