Figure 4.

Lymphopenia prior to reperfusion predicts mortality in STEMI and is associated with admission troponin. (A) Kaplan-Meier survival curves of 4874 consecutive STEMI/pPCI patients discharged alive following pPCI (mean follow-up time of 7.5 years), divided into four quartiles of pre-reperfusion lymphocyte count, with the lowest quartile having worse survival. Survival of each quartile was compared with unadjusted Kaplan-Meier analysis. (B) The same 4874 patients, with the mean admission high-sensitivity cardiac troponin T value (ng/ml) for each lymphocyte quartile, showing that patients with the lowest lymphocytes had the highest troponin values (statistical comparison by unpaired t-tests). (C) Correlation between pre-reperfusion lymphocyte count and left-ventricular ejection fraction between 2-7 days post-reperfusion. Lower lymphocyte count was predictive of worse ejection fraction only in CMV seronegative patients.