Table 3. . Differences in immune cellular compositions between patients with systemic lupus erythematosus and healthy controls.
| Variables | SLE (n = 60) | HC (n = 20) | p-value | |
|---|---|---|---|---|
| Univariate | Multivariate | |||
| B cells | 17.41 ± 11.1 | 12.56 ± 4.02 | NS | |
| T cells | 76.17 ± 11.87 | 73.96 ± 8.32 | NS | |
| CD4+ T cells | 43.59 ± 13.93 | 54.00 ± 8.18 | <0.001 | 0.22 |
| CD8+ T cells | 49.81 ± 14.53 | 36.61 ± 8.12 | <0.001 | 0.22 |
| CD4−CD8− T cells | 5.12 ± 3.67 | 8.61 ± 4.94 | <0.001 | 0.027 |
| CD4+CD8+ T cells | 1.47 ± 1.54 | 0.78 ± 0.34 | 0.028 | 0.379 |
| Tregs | 4.31 ± 2.00 | 6.18 ± 1.31 | <0.001 | 0.095 |
| Monocytes | 1.48 ± 1.56 | 1.58 ± 1.14 | NS | |
| Classical monocytes (CD14+CD16−) |
76.24 ± 14.84 | 80.33 ± 14.62 | NS | |
| Intermediate monocytes (CD14+CD16low) |
11.41 ± 7.10 | 12.65 ± 9.25 | NS | |
| Nonclassical monocytes (CD14+CD16hi) |
11.54 ± 12.16 | 6.64 ± 5.80 | NS | |
| NK cells | 4.70 ± 3.97 | 11.85 ± 7.46 | <0.001 | <0.001 |
| CD56dim NK cells | 85.18 ± 12.14 | 91.23 ± 6.46 | NS | |
| CD56bright NK cells | 14.82 ± 12.14 | 8.77 ± 6.46 | NS | |
| MyDCs | 0.05 ± 0.05 | 0.10 ± 0.05 | <0.001 | 0.571 |
| pDCs | 0.01 ± 0.01 | 0.05 ± 0.03 | <0.001 | 0.092 |
| Basophils | 0.03 ± 0.09 | 0.12 ± 0.12 | <0.001 | 0.649 |
| ILCs | 0.47 ± 0.38 | 0.94 ± 0.60 | <0.001 | 0.014 |
Data of monocytes, MyDCs, pDCs and basophils are expressed as a percentage of live CD45+ white blood cells. Data for B cells, T cells, NK cells and ILCs are expressed as a percentage of live lymphocytes. Data are shown as the mean ± standard deviation. p < 0.05 indicates statistical significance.
HC: Healthy control; ILC: Innate lymphoid cell; MyDC: Myeloid dendritic cell; NK: Natural killer; NS: Not significant; pDC: Plasmacytoid dendritic cell; SLE: Systemic lupus erythematosus.