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PK-PD parameters from i.j. instillations with prototype insulin-dWPI beads (mean ± SD, n = 4−6). Insulin + C10 (100 mM) is historical data and, as such, the % F and % PA were calculated using a different s.c. dataset ([39]).
| Tmax (min) | Cmax (mU/L) | AUC (mU/L.min) | % PA | % F | |
|---|---|---|---|---|---|
| Insulin (s.c.) | 23.3 ± 8.2 | 64.9 ± 22.7 | 3356 ± 995 | - | - |
| Beads | 36.7 ± 19.7 | 87.4 ± 38.8 | 3761 ± 1429 | 2.4 | 2.2 |
| Beads + C10 | 25.0 ± 10.0 | 128.9 ± 105.4 | 7239 ± 6675 | 2.3 | 4.3 |
