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Scheme of chromosomal rearrangements in chromothripsis. During chromothripsis, the chromosome or the chromosome arm was destroyed, followed by incomplete and accidental restoration of fragments (1–12). When the chromosome is restored, the orientation of the fragments can change (fragments 7, 10), some of the fragments are removed (fragments 2, 5, 9, 11, 12), and some form extrachromosomal double minutes (fragments 4). This results in a rearranged chromosome or chromosome fragments.
