Table 7.

Natural products against Hepatitis C virus.

Natural Source	Compound	HCV	Target	CC50 (µg/mL)	EC50-IC50 (µg/mL)	SI or TI	Reference
Trichilia dregeana	Root extract	HCV	Inhibition of viral entry		16.6	37	[94]
Detarium microcarpum	Stem bark extract				1.42	211
Phragmanthera capitata	Leave extract				13.17
Bupleurum kaoi	Saikosaponin B2			740.4 ± 28.35 µM	16.13 ± 2.41 µM	45.9	[95]
Bupleurum kaoi	Methanolic extract			16.82 ± 1.89	215.4 ± 10.7	12.8
Anthocyanidin	Delphinidin				3.7 ± 0.8 μM		[96]
Alloeocomatella polycladia	Ethyl acetate- soluble fraction		Suppression of the helicase activity of HCV NS3		11.7 ± 0.7		[97]
Fusarium equiseti	Crude extracts		Inhibition of HCV NS3/4A protease		19–77 µM		[98]
Eclipta alba	Aqueous extract		Inhibition of HCV NS5B replicase activity		11		[99]
Taraxacum officinale	Flavonoids						[100]
Swietenia macrophylla	3-hydroxy caruilignan C		Reduction of HCV protein and HCV- RNA levels		10.5 ± 1.2μM		[101]
Entada africana	Methylene chloride-methanol (MCM) stem bark crude extract		Broad antiviral activity		453 ± 0.00117		[102]
Grape seed	Phenolic compounds		Suppression of HCV- induced Cox-2		7.5 ± 0.3		[104]
Flavanone	Naringenin		Release/Assembly		109 μM		[107]

CC₅₀: Half maximal cytotoxic concentration; EC₅₀-IC₅₀: Half maximal inhibitory concentration; SI: Selectivity index = CC₅₀/IC₅₀.