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. 2021 May 20;8:435–450. doi: 10.2147/JHC.S307962

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© 2021 Jiang et al.

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Schematic representation of HBV structure. The intact HBV consists of a double envelope and a core granule. The lipid bilayer contains the large, medium and small protein forms on the envelope, collectively known as HBsAg. The surface of the core particle is the true viral capsid, which is composed of the HBcAg. The core particle contains circular and partially double-stranded DNA and polymerase.

Abbreviations: HBsAg, hepatitis B surface antigen; HBcAg, hepatitis B core antigen; HBV, hepatitis B virus.