Table 1.
Expression and function of mesothelial molecular markers during development.
| Gene Name, Molecule Type | Expression in Peritoneum | Role of Protein | |||
|---|---|---|---|---|---|
| Parietal | Intestine | Liver | Pancreas | Knockout | |
| GMP6A (Glycoprotein m6a) | Adult [32] |
Embryonic, adult [67] |
Increase in body fat / body weight [136] |
||
| PDPN (podoplanin) | Embryonic [131] |
E12.5, adult [32,112,126] |
Lymphatic and endothelial phenotype [133,134] |
||
| WT1 (Wilms’ tumour protein 1) | Embryonic, adult [103,104,116] |
Embryonic, adult [103,104,116] |
Embryonic, adult mesothelial and submesothelial [112,113,139] |
Embryonic, adult [114,115] |
Multi-systemic: kidneys, heart, visceral fat, bone, haematopoiesis, pancreas [114,115,117,122] |
| MSLN (Mesothelin) | Embryonic, adult [31,125] |
Embryonic, adult [31,125] |
Embryonic, adult [31,125,126] |
No phenotype [127] |
|
| UPK3B (Uroplakin 3b) | Embryonic, adult [137] |
Embryonic, adult [137] |
Embryonic, adult [137] |
No phenotype [137] |
|
| ALCAM (activated leukocyte cell adhesion molecule) | Embryonic, mesothelial and submesothelial [67,112,139] |
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