Skip to main content
. 2021 May 5;13(5):834. doi: 10.3390/v13050834

Figure 6.

Figure 6

The structures of the M2-1 protein from RSV and HMPV. (A) The linear domain organization of the M2-1 protein. There are three domains: the zinc-binding domain (ZBD, green), an oligomerization domain (OD, cyan), and a core domain (CD, blue). (B) The crystal structure of the RSV M2-1 (PDB: 4C3B). The cartoon representation of the RSV M2-1 is shown in the dotted box. (C) The crystal structure of the HMPV M2-1 (PDB: 4CS7). Note that the protomer in the open state is shown as the same color scheme as in panel A. (D) The crystal structure of the RSV M2-1 in the complex of the PNTD (PDB: 6G0Y). The PNTD is highlighted in magenta, consistent with Figure 4. (E) The crystal structure of the RSV M2-1 in the complex of a short RNA oligo (PDB: 6PZQ). Two RNA molecules are colored in red and orange, respectively. Four protomers are shown in the M2-1 structures. Only one protomer is colored as the domain organization, and the rest are in gray. The PDB accession codes are underlined.