Table 5.
Baseline whole gastro-intestinal permeability in healthy subjects and in CKD patients.
| Healthy Subjects | CKD III B | CKD IV | p | |
|---|---|---|---|---|
| Number | 27 | 11 | 11 | |
| Stomach (sucrose recovery, %) | 0.031 ± 0.006 | 0.019 ± 0.007 | 0.021 ± 0.007 | ns |
| Median | 0.02 | 0.02 | 0.02 | |
| Range | 0.01–0.16 | 0.01–0.03 | 0.01–0.05 | |
| Small intestine (lactulose/mannitol, ratio) | 0.029 ± 0.01 | 0.019 ± 0.01 | 0.03 ± 0.01 | ns |
| Median | 0.017 | 0.018 | 0.017 | |
| Range | 0.005–0.31 | 0.012–0.032 | 0.01–0.1 | |
| Colon (sucralose recovery, %) | 1.03 ± 0.08 | 0.40 ± 0.09 * | 0.30 ± 0.09 * | <0.00001 |
| Median | 0.97 | 0.4 | 0.31 | |
| Range | 0.01–1.95 | 0.25–0.65 | 0.16–0.51 |
Data are expressed as mean ± SEM, median and range. Differences tested by one-way ANOVA followed by Fisher’s LSD Multiple comparison test. Significance levels: * p < 0.05 vs. healthy subjects.