Table 7.

Effect of placebo or synbiotic administration on gastrointestinal permeability in healthy subjects.

Placebo	Baseline	T2	T3	p-Value
Number	14	14	14
Stomach (sucrose recovery, %)	0.027 ± 0.004	0.028 ± 0.004	0.025 ± 0.002	ns
Median	0.02	0.025	0.03
Range	0.01–0.06	0.01–0.06	0.01–0.04
Small intestine (lactulose/mannitol, ratio)	0.018 ± 0.003	0.18 ± 0.002	0.016 ± 0.001	ns
Median	0.016	0.016	0.017
Range	0.009–0.047	0.01–0.05	0.009–0.025
Colon (sucralose recovery, %)	1.03 ± 0.07	1.14 ± 0.09	1.04 ± 0.1	ns
Median	1.04	1.12	0.98
Range	0.64–1.45	0.63–1.64	0.58–2.15
Synbiotic	Baseline	T2	T3	p-Value
Number	10	10	10
Stomach (sucrose recovery, %)	0.037 ± 0.012	0.035 ± 0.007	0.045 ± 0.016	ns
Median	0.02	0.02	0.02
Range	0.01–0.16	0.02–0.07	0.01–0.17
Small intestine (lactulose/mannitol, ratio)	0.042 ± 0.025	0.015 ± 0.002	0.017 ± 0.002	ns
Median	0.018	0.015	0.015
Range	0.005–0.31	0–0.022	0.011–0.031
Colon (sucralose recovery, %)	1.04 ± 0.17	0.98 ± 0.07	1.13 ± 0.13	ns
Median	0.94	0.92	1.17
Range	0.01–1.95	0.76–1.44	0.45–1.68

Data expressed as mean ± SEM, median and range. Differences tested by one-way ANOVA followed by Fisher’s LSD Multiple comparison test.