Table 2.
Selected plant extracts from different species with identified phenolic compounds and their in vitro effect on dermal fibroblast cells and migration capacity.
| Name of the Families | Name of the Species (Common Names) |
Part of the Plant | Type of Extract (Concentrations) |
Identified Bioactive | Cell Lines | Mechanisms of Action | Ref. |
|---|---|---|---|---|---|---|---|
| Amaranthaceae |
Alternanthera sessilis (L.) R.Br. ex DC. (sessile joyweed) |
stems | Ethanolic (12.5 to 50 μg/mL) |
2,4-dihydroxy-2,5-dimethyl-3(2H)-furan-3-one, hexadecanoic acid, 2-1,2,4-trioxolane,3-phenyl, palmitate ethyl, and L-glutamic acid | HDFs and diabetic HDFs | Increased migratory rate | [95] |
| Fabaceae | Cenostigma pluviosum (DC.) Gagnon & G.P.Lewis | stem bark | ethanolic | pyrogallol, gallic acid, gallic acid methyl ester, ellagic acid, corilagin, 1,4,6-tri-O-galloyl-glucose, tellimagrandin I, 1,2,3,6-tetra-O-galloyl-glucose, mallotinic acid, tellimagrandin II, 1,2,3,4,6-penta-O-galloyl-glucose, geraniin, and mallotusinic acid | HDFs | Increased cell proliferation rate | [96] |
| Lamiaceae | Thymus sipyleus Boiss. | aerial parts | ethanolic (50 to 200 μg/mL) |
luteolin-7-O-glucoside | 3T3 fibroblasts | Increased migratory rate | [97] |
| Primulaceae |
Lysimachia nummularia L. (creeping jenny) |
leaves | ethanolic (10 to 50 μg/mL) |
various phenolic acid, flavonoid, and anthocya-nin derivatives |
3T3 fibroblasts | Increased migratory rate | [77] |
| Rosaceae | Alchemilla vulgaris L. | whole plant | ethanolic | kaempferol, luteolin, apigenin-7-Oglucoside, luteolin-7-O-glucoside, isoquercetin, and ellagic acid | L929 fibroblasts | Increased migratory rate | [98] |