Table 3.
Various formulations prepared for identifying and screening the highest and lowest concentrations of independent variables.
| No. | Surfactant/Co-Solvent Type | Drug (%) |
Manual Observation | |||
|---|---|---|---|---|---|---|
| A | B | C | D | |||
| F1 | 8.9 | - | - | - | 0.6 | Settling of curcumin on keeping overnight. Crystals of curcumin seen in microscope. |
| F2 | 8.9 | 5 | - | - | 0.6 | Settling of curcumin on keeping overnight. Crystals of curcumin seen in microscope. |
| F3 | 8.9 | 8 | - | - | 0.6 | No settling of curcumin but crystals of curcumin were seen under microscope. |
| F4 | 8.9 | - | 5 | - | 0.6 | Settling of curcumin observed. |
| F5 | 8.9 | - | 8 | - | 0.6 | No settling of curcumin but crystals of curcumin were seen under the microscope. Gelucire was expelled out. |
| F6 | 8.9 | 5 | 5 | - | 0.6 | No settling of curcumin but crystals of curcumin were seen under the microscope. Gelucire was expelled out. |
| F7 | 8.9 | 5 | 8 | - | 0.6 | No settling of curcumin but crystals of curcumin were seen under microscope. Gelucire was expelled out. |
| F8 | 8.9 | - | - | 5 | 0.6 | Settling of curcumin observed. |
| F9 | 8.9 | - | - | 8 | 0.6 | Settling of curcumin observed. |
| F10 | 8.9 | 5 | 8 | 0.6 | Crystals of curcumin observed under the microscope. | |
| F11 | 8.9 | 5 | 10 | 0.6 | Crystals of curcumin observed under the microscope. | |
| F12 | 8.9 | 8 | 10 | 0.6 | Crystals of curcumin were not observed under the microscope. | |
| F13 | 12 | 5 | - | - | 0.6 | Crystals of curcumin observed under the microscope. |
| F14 | 12 | 8 | - | - | 0.6 | Crystals of curcumin were observed under the microscope. |
| F15 | 12 | - | - | 5 | 0.6 | Crystals of curcumin observed under the microscope. |
| F16 | 12 | - | - | 8 | 0.6 | Crystals were not observed under microscope until 4 weeks. |
A = Tween 80, B = PEG 400, C = Gelucire14/44, D = PEG 600.