Table 6.
Stability studies on optimized CSLN formulation (n =3).
| Temperature | Months | % Decrease | % Increase in Particle Size |
PDI | |
|---|---|---|---|---|---|
| TDC | % Entrapment | ||||
| 5 ± 3 °C | 0 | - | - | - | 0.206 ± 0.016 |
| 1 | 0.78 ± 0.25 | 0.260.06 | 0.03 ± 0.00 | 0.213 ± 0.041 | |
| 3 | 1.80 ± 0.10 | 0.48 ± 0.06 | 0.03 ± 0.00 | 0.242 ± 0.026 | |
| 6 | 3.75 ± 1.61 | 4.75 ± 0.10 | 2.08 ± 2.23 | 0.242 ± 0.020 | |
| 12 | 5.56 ± 1.01 | 7.36 ± 0.89 | 9.24 ± 1.40 | 0.278 ± 0.015 | |
| 30 ± 2 °C; 65% ± 5% RH |
0 | - | - | - | 0.227 ± 0.003 |
| 1 | 1.26 ± 0.40 | 0.54 ± 0.10 | 4.87 ± 0.36 | 0.307 ± 0.014 | |
| 3 | 2.15 ± 0.57 | 1.48 ± 0.10 | 19.93 ± 1.88 | 0.313 ± 0.031 | |
| 6 | 4.25 ± 0.98 | 6.26 ± 0.94 | 52.17 ± 4.19 | 0.294 ± 0.047 | |
| 12 | 9.80 ± 1.07 | 10.5 ± 1.48 | 72.21 ± 2.90 | 0.352 ± 0.000 | |