Table 1.
Multiancestry GWAS Sample Population Group | Replication Sample Population Group | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | European | African | East Asian | Hispanic | European (UK Biobank) |
African (AFR CA UG) |
||||||||
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
No. of participants | 107,247 | 127,006 | 85,554 | 91,972 | 10,368 | 10,986 | 8,611 | 18,809 | 2,714 | 5,239 | 6,852 | 193,117 | 1,586 | 1,047 |
No. with individual level data a | 84,574 | 65,134 | 71,570 | 52,531 | 9,126 | 8,702 | 1,652 | 1,803 | 2,226 | 2,098 | 6,852 | 193,117 | 1,586 | 1,047 |
No. ≤ 55 years of age | 8,959 | 13,562 | 7,099 | 11,471 | 1,628 | 1848 | 47 | 81 | 185 | 162 | 481 | 79,347 | 354 | 277 |
No. with aggressive disease b | 26,374 | - | 21,917 | - | 2,934 | - | 753 | - | 770 | - | - | - | - | - |
These participants are also included in GRS and stratified analyses.
Aggressive disease defined as stage T3/T4, regional lymph node involvement (N1), metastatic disease (M1), a tumor with a Gleason Score ≥ 8, or a prostate-specific antigen (PSA) level ≥ 20 ng/mL, or, prostate cancer as the underlying cause of death.