Figure 4.

The NIR fluorescence imaging and antitumor efficacy in vivo. (A) In vivo fluorescence images of tumor-bearing mice at different time points after intravenous injection of IR780, CLs@IR780 and MFLs@IR780. (B) The relative tumor volume (C) the images of the tumor-bearing mice (D) tumor mass after treated 14 days with different preparations (n = 6). The detection of Fe²⁺ (E), ROS (F) and PpIX (G) in tumor tissues. The tumor tissues were exfoliated from different groups after treated 14 days with different preparations. Scale bar = 50 μm. Data are presented as means ± SD (n = 3). ∗∗∗∗P < 0.0001, ∗∗P < 0.01.