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. 2020 Dec 15;11(5):1200–1212. doi: 10.1016/j.apsb.2020.12.008

Figure 6.

Figure 6

Celastrol inhibits resistin-induced cytokines levels. (A) ELISA quantification of resistin level in mouse serum. (B) Resistin staining in epididymal adipose tissue and liver tissue of mice. (C) Resistin expression in mice liver was determined by Western blot. (D) ELISA quantification of cAMP level in cell supernatant. (E) PKA‒NF-κB signaling in PMA-differentiated THP-1 cells were determined by Western blot analysis after celastrol treating. (F) Immunofluorescence staining of PMA-differentiated THP-1 cells were treated with celastrol for 2 h, and then stimulated with resistin for 15 min. (G) ELISA quantification of protein levels of cytokines in cell supernatant. Data represent as mean ± SEM. P values are determined by two-tailed Student's t test (n = 3). ∗P < 0.05, ∗∗P < 0.01, ns, not significant.