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. 2020 Nov 6;11(5):1300–1314. doi: 10.1016/j.apsb.2020.11.001

Table 2.

In vitro metabolic stability of 21b, 21c and lovastatin in mouse liver microsomes.

Compd. t1/2 (min)a CLint (mL/min/kg)a
Lovastatin 0.73 7516
21b 4.18 415.81
21c 87.5 62.37
a

The data are mean of duplicate. Additional data are shown in the Supporting Information Table S21 and Fig. S8.