Table 3.

Spearman rank correlation coefficient (Spearman’s rho) among the specific genes in equine embryos.

Function		Growth & Development							Embryo-Maternal Communication			Methylation			Apoptosis
	Gene	IGF2-	H19	POU5F1	SOX2	IGF1	NANOG	ATPA1A	ESR1	CYP19A1	PTGES2	DNMT1	DNMT3a	DNMT3b	BCL2	BAX
Growth & Development	IGF2	1
	H19	0.4 *	1
	POU5F1	0.26	−0.05	1
	SOX2	0.21	−0.14	0.74 ***	1
	IGF1	−0.06	0.34	0.74 ***	−0.66 **	1
	NANOG	0.07	−0.27	0.73 ***	0.89 ***	−0.63 **	1
	ATPA1A	−0.04	0.06	−0.66 ***	−0.46 *	0.56 *	−0.34	1
Embryo-maternal communication	ESR1	0.04	−0.05	0.33	0.45	−0.43	0.2	0.18	1
	CYP19A1	−0.24	0.4 *	−0.74 ***	-0.59 **	0.49 *	−0.51 *	0.5 *	−0.12	1
	PTGES2	0.14	0.16	−0.1	0.14	0.03	0.26	0.37	0.15	0.1	1
Methylation	DNMT1	−0.23	0.29	−0.11	0.1	0.49 *	0.19	0.45 *	0.27	0.47 *	0.7 ***	1
	DNMT3a	−0.12	0.19	0.32	0.5	0.02	0.58 **	0.14	0.54	−0.04	0.45 *	0.65 ***	1
	DNMT3b	−0.04	−0.05	0.75 ***	0.82 ***	−0.59 **	0.91 ***	−0.36	0.29	−0.39	0.3	0.29	0.57 **	1
Apoptosis	BCL2	−0.04	0.24	0.21	0.05	0.01	0.14	0.03	0.38	0.09	−0.07	0.23	0.43	0.07	1
	BAX	0.07	−0.22	0.77 ***	0.55 **	−0.69 **	0.58 **	−0.6 **	0.34	−0.54 **	−0.04	−0.12	0.05	0.67 ***	−0.02	1

Color gradient to indicate where each Spearman correlation coefficient value falls within the range, blue = −1 to red = 1 R value. Statistical significance for the correlation coefficient is represented as * p < 0.05, ** p < 0.01, *** p < 0.001.