Table 1.

Inactivated whole-cell vaccines and subunit vaccines explored for controlling tilapia streptococcosis.

Vaccine	RPS	Adjuvant	Vaccination	Challenge	Year	Reference
Inactivated	49–80%	Without	Intraperitoneal	Intraperitoneal	2004–2005	[69,70,71]
Inactivated	97%	Without/feed-based adjuvant	Oral	Intraperitoneal	2004	[71]
Sip	57%	--	Intragastrical	Intraperitoneal	2014	[79]
tSip	90%	FIA	Intraperitoneal	Intraperitoneal	2014	[78]
PGK	82.4%	Montanide ISA 763 AVG	Intraperitoneal	Intraperitoneal	2014	[80]
OCT	58.8%	Montanide ISA 763 AVG	Intraperitoneal	Intraperitoneal	2014	[80]
GapA	63.3%	FCA + FIA	Intraperitoneal	Intraperitoneal	2016	[75]
GapA	45.6%	Montanide ISA 763 AVG	Intraperitoneal	Intraperitoneal	2016	[75]
FbsA	40.63%	Adjuvant	Intraperitoneal	Intraperitoneal	2014	[82]
Enolase	62.50%	Adjuvant	Intraperitoneal	Intraperitoneal	2014	[82]
LIC	70%	Without	Feed-based	Intraperitoneally	2014	[85]
GroEL	68.61%	FCA + FIA	Subcutaneous	Intraperitoneally	2019	[74]
CWSAP 465	77.5%	FIA	Intraperitoneal	Intraperitoneal	2016	[86]
CWSAP1035	72.5%	FIA	Intraperitoneal	Intraperitoneal	2016	[86]
ISP	48.61%	FCA + FIA	Intraperitoneal	Intraperitoneal	2016	[87]
SAG	86.67%	--	Intraperitoneal	Intraperitoneal	2018	[73]

Notes: Inactivated—inactivated whole-cell vaccine, RPS—relative percentage of survival, FIA—Freund’s incomplete adjuvant, FCA—Freund’s complete adjuvant,—DNA vaccine without adjuvant, without—without adjuvant, LIC—cell wall surface anchor family protein, CWSAP—cell wall surface anchor family protein, ISP—immunogenic secreted protein.