Table 3.

Efficacy of different COVID-19 vaccines after the first and second doses.

				Vaccine					Placebo
Shot	Antigen/Antibody	After Injection (Week)	Vaccine Type	Studies N	Efficacy	Lower Limit	Upper Limit	I-Squared	Studies N	Efficacy	Lower Limit	Upper Limit	I-Squared
After 1st dose	RBD	2	Adenovirus-based	4	0.603	0.471	0.722	73.8	2	0.004	0.001	0.027	0
			Inactivated	4	0.870	0.734	0.983	93.8	4	0.024	0.008	0.072	0
		3	Adenovirus-based	2	0.976	0.939	0.997	0.0	NA	NA	NA	NA	NA
			VLP	8	0.238	0.091	0.375	84.3	NA	NA	NA	NA	NA
		4	Adenovirus-based	2	0.966	0.942	0.980	0.0	2	0.004	0.001	0.027	0
			Inactivated	4	0.913	0.564	0.958	90.7	4	0.061	0.033	0.110	0
			Pro-Subunit	6	0.628	0.590	0.665	0.0	NA	NA	NA	NA	NA
	S-protein	2	Inactivated	2	0.293	0.182	0.437	0.0	2	0.083	0.032	0.202	0
		3	Pro-Subunit	4	0.790	0.474	0.874	91.0	4	0.021	0.005	0.079	0
		4	Inactivated	2	0.396	0.269	0.539	0.0	2	0.021	0.003	0.134	0
			Pro-Subunit	4	0.873	0.671	0.892	91.9	4	0.021	0.005	0.079	0
	NAb	2	Inactivated	4	0.583	0.210	0.868	95.0	4	0.030	0.013	0.070	0
		3	Pro-Subunit	4	0.551	0.291	0.786	85.0	4	0.021	0.005	0.079	0
		4	Adenovirus-based	2	0.547	0.496	0.596	76.8	2	0.008	0.002	0.031	0
			Inactivated	4	0.691	0.537	0.812	95.0	4	0.025	0.008	0.074	0
			mRNA-based	4	0.702	0.655	0.746	73.9	4	0.010	0.004	0.026	0
After 2nd dose	RBD	2	Inactivated	9	0.929	0.876	0.960	61.8	9	0.171	0.077	0.336	85
			mRNA-based	5	0.731	0.532	0.866	86.0	NA	NA	NA	NA	NA
		3	Adenovirus-based	3	0.982	0.980	0.984	0.0	1	0.149	0.139	0.159	0
			VLP	9	0.787	0.581	0.908	78.1	NA	NA	NA	NA	NA
		4	Inactivated	4	0.944	0.842	0.982	15.9	4	0.063	0.026	0.143	0
			Pro-Subunit	6	0.956	0.937	0.970	0.0	NA	NA	NA	NA	NA
	S-protein	2	Inactivated	7	0.941	0.877	0.973	61.4	7	0.290	0.139	0.507	87
			Pro-Subunit	18	0.852	0.719	0.928	62.4	18	0.028	0.014	0.052	0
			mRNA-based	5	0.786	0.725	0.836	0.0	NA	NA	NA	NA	NA
		4	Inactivated	4	0.934	0.842	0.974	15.9	4	0.063	0.026	0.143	0
			Pro-Subunit	14	0.792	0.679	0.873	50.7	15	0.031	0.015	0.061	0
	NAbs	2	Adenovirus-based	1	0.999	0.985	1.000	0.0	NA	NA	NA	NA	NA
			Inactivated	9	0.845	0.724	0.919	86.5	9	0.151	0.068	0.303	85
			Pro-Subunit	23	0.753	0.667	0.823	68.2	19	0.028	0.015	0.052	0
			mRNA-based	9	0.870	0.747	0.938	82.4	4	0.008	0.003	0.024	0
		3	Adenovirus-based	1	0.958	0.955	0.961	0.0	1	0.071	0.065	0.079	0
		4	Adenovirus-based	1	0.999	0.985	1.000	0.0	NA	NA	NA	NA	NA
			Inactivated	4	0.700	0.375	0.901	86.1	4	0.033	0.011	0.099	0
			Pro-Subunit	17	0.759	0.574	0.881	62.9	15	0.031	0.015	0.061	0
			mRNA-based	4	0.995	0.980	0.999	0.0	4	0.016	0.007	0.035	0

S-protein = spike protein, Alum = aluminium, CpG = cytosine-guanine oligodeoxynucleotide, AS03 = squalene-based immunologic adjuvant, RBD = receptor-binding domain, NAb = neutralizing antibody, Pro-Subunit = protein subunit, NA = not available.