Table 7.

Binding interactions of the best T-cell epitopes of the SARS-CoV-2 variants with their MHC I alleles.

S.No.	Potential Peptide for Vaccine	Binding Alleles	Attractive vdW	Repulsive vdW	ACE	HB	Global Energy
Wuhan Isolate
1.	ILDITPCSF	HLA-B*51:01	−28.64	7.59	−9.54	−2.23	−58.28
		HLA-B*08:01	−24.90	5.90	−8.27	−3.92	−50.66
		HLA-A*02:06	−24.14	10.32	−9.30	−2.48	−49.01
2.	STQDLFLPF	HLA-A*32:01	−19.73	14.97	−11.66	−1.83	−44.18
		HLA-B*57:01	−29.53	21.42	−3.31	−3.03	−40.05
		HLA-B*15:01	−3.50	0.00	0.36	0.00	−8.53
3.	VVFLHVTYV	HLA-B*51:01	−29.19	10.45	−1.43	−3.35	−51.05
		HLA-A*02:03	−18.26	2.58	−9.10	−4.13	−42.85
4.	GVVFLHVTY	HLA-B*35:01	−36.19	7.98	−8.72	−1.99	−66.28
		HLA-A*01:01	−32.13	6.50	−7.59	−2.76	−55.83
		HLA-B*15:01	−9.36	2.62	0.96	−0.20	−3.98
5.	WTAGAAAYY	HLA-B*35:01	−27.77	4.34	−2.83	−3.28	−54.98
		HLA-A*01:01	−30.65	13.59	−7.64	−4.80	−53.52
6.	GAAAYYVGY	HLA-A*30:02	−25.83	3.78	−4.26	−4.52	−51.90
		HLA-B*15:01	−20.22	7.80	−0.58	−0.99	−24.32
England Isolate
7.	QYIKWPWYI	HLA-A*23:01	−25.46	8.91	−13.16	−0.95	−57.28
		HLA-C*06:02	−29.14	16.66	−4.45	−3.18	−50.48
8.	GVYFASTEK	HLA-A*30:01	−21.73	4.79	2.52	−3.41	−28.36
9.	NGVEGFNCY	HLA-B*35:01	−37.69	6.42	2.02	−2.25	−46.33
10.	PYRVVVLSF	HLA-A*23:01	−25.49	9.71	−11.33	−2.48	−65.01
		HLA-C*14:02	−25.48	5.04	−1.94	−0.95	−41.16
11.	VYAWNRKRI	HLA-A*23:01	−22.44	4.18	−4.02	−3.34	−46.75
12.	SPRRARSVA	HLA-B*07:02	−25.14	8.95	3.94	−1.97	−18.83
USA Isolate
13.	IAIVMVTIM	HLA-B*51:01	−30.57	25.38	−16.59	−0.98	−59.86
14.	LPFNDGVYF	HLA-B*35:01	−35.26	47.18	−3.06	−3.78	−30.68
Indian Isolate
15.	YQPYRVVVL	HLA-B*08:01	−36.00	10.43	−7.97	−2.46	−62.85
16.	YSKHTPINL	HLA-A*68:02	−22.93	6.44	−10.43	−2.56	−59.11
17.	FTISVTTEI	HLA-A*68:02	−29.71	11.47	−7.29	−2.07	−53.01
18.	WTAGAAAYY	HLA-A*26:01	−31.19	8.71	−0.08	−1.66	−44.75
19.	GAAAYYVGY	HLA-A*30:02	−19.74	5.30	−9.59	−2.21	−43.65
South African Isolate
20.	IAIPINFTI	HLA-B*51:01	−22.76	6.82	−13.73	−0.80	−54.96
21.	FTISVTTEI	HLA-B*51:01	−22.68	11.47	−7.29	−7.29	−53.01
22.	QLTPTWRVY	HLA-B*35:01	−19.09	8.37	−10.39	0.00	−44.39
23.	YSKHTPINL	HLA-B*57:01	−24.90	3.82	−1.65	−1.65	−41.72
24.	YQPYRVVVL	HLA-B*08:01	−21.47	10.07	−9.41	−0.98	−38.80