Age from 30 to 65 years |
Age under 30 and over 65 years |
Mild form of respiratory SARS-CoV-2 disease |
Severe or critical form of SARS-CoV-2 pulmonary infection |
Non-specific neurological symptoms such as smell and taste dysfunction, vertigo, headache, dizziness or fatigue |
Disturbance in consciousness, acute cerebrovascular disease (ischemic stroke, cerebral hemorrhage, subarachnoid hemorrhage), acute encephalopathy, encephalitis or meningitis, polyneuropathy, demyelinating spectrum of disease and seizures. |
SARS-CoV infection from 30 to 60 days before TCCD recording |
More than 60 days from infection start and TCCD recording |
Treated exclusively with supportive therapy |
Use of antibiotics, corticosteroids, oxygen for SARS-CoV-2 infection |
Diagnosis confirmed by a positive result of real-time reverse PCR test by nasal/pharyngeal swabs |
History of uncontrolled hypertension, nonregulated diabetes mellitus, cerebrovascular disease, hematologic disease, atrial fibrillation, chronic heart disease or cancer |
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Severe alcohol consumption (more than 10 drinks per week) |
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Stenosis of extracranial vertebrobasilar artery > 20% |
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Stenosis of extracranial carotid artery > 20%. |
For control group negative real time reverese PCR test by nasal/pharyngeal swabs Negative serological IgM and IgG test on SARS-CoV-2 virus |
Known occlusive disease of intracranial cerebral arteries |
No SARS-CoV-2 symptoms at all |
Using anticoagulant drug, vasodilatory drugs, hormone replacement therapy, β-blocking agents, calcium channel blockers |