Table 3.
Amino acid mutations fixed in the lineage leading to the 2020 Spanish outbreak studied.
| Mutation | Protein | Function |
|---|---|---|
| A52T | Capsid protein C | Form the nucleocapsid |
| V642M | Envelope E | Binding host cell surface and mediates membranes fusion |
| R769K | Envelope E | Binding host cell surface and mediates membranes fusion |
| K961R | NS1 | Role in early RNA replication |
| G1354R | NS2A | Component of the viral RNA replication complex |
| T1941A | NS3 | In association with NS2B, performs its autocleavage |
| F2290L | 2k | Signal peptide for NS4B |
| D2414N | NS4B | Induces the formation of ER-derived membrane vesicles |
| R2434G | NS4B | Induces the formation of ER-derived membrane vesicles |
| K2569R | NS5 | RNA-directed RNA polymerase |